Science
Function of NAD+ in the Body:
Energy Production:
Nicotinamide adenine dinucleotide (NAD+/NADH) is a coenzyme essential for cellular energy production. It plays a vital role in redox reactions, which are critical for converting food into ATP, the cell's energy currency.[1]
DNA Repair:
As we age, DNA damage accumulates, contributing to cellular dysfunction. NAD+ is involved in activating enzymes that repair damaged DNA.[2]
Cellular Signalling:
NAD+ is also involved in various cellular signalling pathways, influencing gene expression and other vital cellular functions.[1]
Sirtuin Activation:
NAD+ is a cofactor for sirtuins, a family of proteins that regulate various biological processes, including inflammation, stress response, and metabolism. Sirtuins are thought to play a key role in longevity.[3]
Restore NAD+ here
What Happens When NAD+ is Depleted:
Mitochondrial Dysfunction:
Declining NAD+ and an altered NAD+/NADH redox balance can impair mitochondrial function, leading to reduced energy production and increased oxidative stress.[4]
DNA Damage Accumulation:
Reduced NAD+ availability impairs DNA repair, resulting in the accumulation of DNA damage that may contribute to age-related diseases.[5]
Sirtuin Inactivity:
Lower NAD+ levels decrease sirtuin activity, disrupting the regulation of key cellular processes.[6]
Increased Age Related Conditions:
The reduction of NAD+ has been associated with several health conditions.[7]
Replenish NAD+ here
How Supplementation May Help:
Supplementation with NAD+ precursors, like NMN has been shown to help increase NAD+ levels measured in the body.[8,9]
Taking NAD+ precursor supplements have been linked to a range of potential benefits.[10,11]
As research on the biology of NAD+ is still ongoing, more studies will continue to reveal full picture of NAD+ and healthy aging.
Get NMN here
Why NMN?
Our bodies have multiple pathways to produce NAD+ from a range of precursors.
NAD+ itself is unstable and poorly bioavailable as an oral supplement. However, precursors to NAD+ such as NR or NMN have been shown to be readily absorbed via the gut.
Nicotimanide Mononucleotide (NMN) has been show to be bioavailable, readily absorbed through the gut and converted in only one enzymatic step to NAD+.[12]
Is NMN safe?
Studies have shown NMN to be safe to consume regularly in moderate amounts.[12.1]
Our chosen capsule content of 500mg per daily capsule sits well within reported safety levels.
Figuring out how much should be taken may depend on a person's individual biology. Some people may be more sensitive to the effects of NMN or metabolise it faster than others.
The gut microbiome, which can vary hugely between people, is thought to play an important role in it's absorption and conversion to NAD+.
And we will evolve our solutions as the science of personalised NAD+ precursor intake develops.